Types of Vitiligo
Generalized Vitiligo/ Non-Segmental Vitiligo
Generalized Vitiligo, also known as Non-Segmental Vitiligo, is a skin condition characterized by the development of white patches on the skin. It is believed to be a result of free radical damage in the body, which can potentially be considered as lifestyle disoder. Free radicals are harmful toxins that are produced during metabolic processes.
It is worth noting that autoimmunity refers to the immune system mistakenly attacking the body’s own cells.The onset of autoimmunity may not be the primary sole causative factor in Non-Segmental Vitiligo. Instead, individuals with this type of vitiligo may have genetic susceptibility in their melanocytes, the cells responsible for producing skin color which can not handle the toxins. Alternatively, they may have an increased production of free radicals or a decreased ability to neutralize them. Once cells are damaged, the autoimmunity sets in and removes the colour giving cells and hence white patches in skin.
In Non-Segmental Vitiligo, autoimmunity may not play a significant role in the initial stages of the disease. This could be an affect in response to the other cause/triggers. Hyperactive immune system due to a genetic susceptibility also a concern here.
Additionally, many patients with Non-Segmental Vitiligo often have a deficiency in Vitamin D. This vitamin plays a crucial role in preventing autoimmunity. However, it is important to highlight that a genetic susceptibility to vitiligo does not necessarily mean that the condition is hereditary.
Therefore, in the case of Non-Segmental Vitiligo, it is likely that there are genetic susceptibility at various levels mentioned above. However, the development of vitiligo requires the presence of multiple external and internal factors to trigger the condition.